Fig. 8: Maturation and Release

1 and 2. The small subgenomic mRNAs coding for the N protein are translated by cytoplasmic ribosomes where they then bind to the genomic (+) ss RNAs to form viral nucleocapsids.
3. Other small subgenomic mRNAs coding for viral structural protein such as the S, M, and E proteins, as well as a few other non-structural viral proteins, are translated at the ribosomes of the rough endoplasmic reticulum (ER) where they enter the ER.
4. The ER then packages these proteins and transports them to the Golgi by way <b> -to-Golgi intermediate compartments (ERGIC) containing the S, M, and E proteins. Viral nucleocapsids in the cytoplasm bind to the ERGICs and are pulled in forming the viral envelope embedded with S, M, and E proteins.
5. The intact viruses are then packaged in smooth secretion vesicles by the Golgi.
6. The intact viruses are then released from the host cell by exocytosis.

Illustration of Maturation and Release .jpg by Gary E. Kaiser, Ph.D.
Professor of Microbiology, The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://cwoer.ccbcmd.edu/science/microbiology/index_gos.html.

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Last updated: Feb., 2021
Please send comments and inquiries to Dr. Gary Kaiser